For example, GWAS studies have identified that variants at some of our differentially methylated loci are associated with adiposity-related traits: total energy total energy expenditure [CDHR3 (39)], energy intake [PTPRN2 (39)], lipoprotein-a levels [DSCAML1 (40)], adiponectin levels [CREG2 (41)], and type 2 diabetes [ANK1, RBMS1 (42–44)]. This evidence concerns the gene ANK1 and type 2 diabetes mellitus.