NR0B2 and cardiac hypertrophy: Consistent with the increased expression of cell growth-related proto-oncogenes, SHP KO mice exhibited higher LV masses than the WT mice (76.8 ± 20.5 mg vs. 52.8 ± 6.8 mg, P = 0.0093), reflecting cardiac hypertrophy, although there was no difference in ejection fraction or fractional shortening of SHP KO and WT mice (Table 1).