Although its role in CDI pathogenesis has been unclear, the presence of binary toxin in combination with a single-nucleotide deletion at base pair 117 within the negative toxin regulator gene tcdC is considered a hallmark for ‘hypervirulent’ 027/NAP1/BI (PCR-ribotype 027 or NAP1 according to pulse-field gel electrophoresis typing, or BI according to restriction enzyme analysis typing) strains which have caused several important outbreaks of severe CDIs [6]. Here, CXCL8 is linked to clostridium difficile infection.