Until now, no association of AMBRA1 genotypes with autistic features has been described in humans, therefore still questioning the construct-validity of our mouse model.29 However, a recent GWAS on schizophrenia identified a genetic risk variation on chromosome 11 (11p11.2) in a region containing AMBRA1.35 Schizophrenia and ASD show considerable syndromic overlap, including deficits in social cognition and communication,24, 36 and at least a subgroup of schizophrenia is also regarded as a disorder of the synapse.37 Here, AMBRA1 is linked to schizophrenia.