AMBRA1 and autism: Another frequently observed trait, connected with autistic behaviors, not only in syndromic forms of autism, is epileptic seizures.9, 10 Most likely, seizure predisposition reflects the autism-pathognomonic neuronal excitation–inhibition dysbalance.4, 11, 12, 13, 14, 15 In our Ambra1+/− model, prepubertal female mutants displayed reduced response to PTZ, namely longer latency to the first whole-body seizure and decreased seizure score compared to female WT (Figure 5b).