AMBRA1 and epilepsy: Epileptic seizures are frequently observed, not only in syndromic autism, where they are often intractable,9, 10 and mirror neuronal excitation/inhibition dysbalance.4, 11, 12, 13, 14, 15 Also here, Ambra1+/− mice revealed a striking sexual dimorphism and may serve as future model to study and treat autism-associated epilepsy.