Moreover, Zwerger and colleagues tested both skin fibroblasts from laminopathic patients and Lmna+/− MEFs expressing different lamin mutations, showing that those exhibiting muscular phenotypes (as dystrophy and DCM) have more deformable nuclei, due to an impairment of the nuclear lamina assembly [53]. This evidence concerns the gene LMNA and familial dilated cardiomyopathy.