Furthermore, the hormones inhibit the crosstalk between Ras-MEK 1/2-ERK 1/2 kinase cascade and the pathways of VEGF, β-catenin, JNK, WNT, and STAT3, leading to the inhibition of the proto-oncogenes c-FOS and c-JUN in the nucleus of cancer cells [48,49] (Figure 3). The gene discussed is MAP2K1; the disease is cancer.