The favorable improvement in lipids (LDL-c, apo A1, and apo B) could have implications for lowering cardiovascular risk in patients with pre- or early diabetes because the plasma concentrations of atherogenic lipoprotein particles, measured by apo B and apo A1, strongly predict factors related to the development of coronary heart disease compared to non-HDL-c [36]. The gene discussed is APOB; the disease is diabetes mellitus.