In addition, fisetin inhibited the proliferation of melanoma cells [19,20], as well as ultraviolet B (UVB)-induced phosphoinositide 3-kinase (PI3K) expression, protein kinase B (PKB; AKT) phosphorylation, and NF-κB activation in the skin of SKH-1 mice [19]. The gene discussed is AKT1; the disease is melanoma.