TNFSF10 and neoplasm: Moreover, TRAIL-Cur-NPs induced a noticeably higher inhibiting effect on tumor growth (151.10 ± 46.12 mm3) than free TRAIL + Cur group (463.69 ± 44.68 mm3, p < .05) due to the higher drug accumulation in the tumor regions via the passive targeting of nanoparticles and active targeting capability provided by TRAIL.