Emerging evidence has demonstrated that Wnt/β‐catenin is activated after gastric cancer and plays a critical role in promoting invasion and migration through overexpressing or increasing the functions of several components of the Wnt pathway such as Wnt1, Wnt2, Wnt3, Wnt5a, Fzd‐3, CTNNB1 and LRP6. The gene discussed is FZD3; the disease is gastric cancer.