Although a very recent study revealed that TIPE1 induced apoptosis in hepatocellular carcinoma cells by negatively regulating Rac1 pathway, indicating that the loss of TIPE1 may be a new prognostic indicator for patients with hepatocellular carcinoma 10, we did not observed that TIPE1 significantly induced apoptosis and inhibited cell growth of gastric cancer (Fig. S6). Here, RAC1 is linked to hepatocellular carcinoma.