Emerging evidence has demonstrated that Wnt/β‐catenin is activated after gastric cancer and plays a critical role in promoting invasion and migration through overexpressing or increasing the functions of several components of the Wnt pathway such as Wnt1, Wnt2, Wnt3, Wnt5a, Fzd‐3, CTNNB1 and LRP6. This evidence concerns the gene LRP6 and gastric cancer.