TIPE2 expression was decreased human hepatic cancer 12 and gastric cancer tissues 13, and reduced TIPE2 expression is associated with metastasis 14. In contrast, TIPE2 expression was increased in the tumour tissues of patients with renal cell carcinoma and positively correlated with TNM staging 15. This evidence concerns the gene TIPE2 and hereditary clear cell renal cell carcinoma.