RAC1 and gastric cancer: Although a very recent study revealed that TIPE1 induced apoptosis in hepatocellular carcinoma cells by negatively regulating Rac1 pathway, indicating that the loss of TIPE1 may be a new prognostic indicator for patients with hepatocellular carcinoma 10, we did not observed that TIPE1 significantly induced apoptosis and inhibited cell growth of gastric cancer (Fig. S6).