Consistent with the previously described tumor suppressive role for SIRT6, its overexpression results in suppressed CSC activity in breast, lung, and colorectal cancer cells with PI3K activation as evidenced by the decreased tumorsphere‐forming capacity and size of ALDH+ cell population which are established readouts of CSCs (Ioris et al., 2017). The gene discussed is LDHA; the disease is neoplasm.