More specifically, AKT1 is a downstream mediator of the PI3K pathway that regulates synaptic formation and plasticity and which imbalance leads to autism and schizophrenia (Enriquez-Barreto and Morales, 2016); genetic variations in contactins (CNTN) have been described in association with neurodevelopmental disorders, including autism. Here, AKT1 is linked to schizophrenia.