PTPN22 and infection: Known immune inhibitors such as SMAD6 that inhibits TGF-beta anti-inflammatory signaling, PTPN22, a phosphatase repressor of IFNG activation of myeloid cells, RAB7B as a moderator (through lysosome degradation mechanisms) of TLR-IFN responses in human dendritic, and to some extent SQSTM1 with roles in autophagy and IFNG host defense, were all actively expressed in mock-infected cells, but their expression is repressed upon infection (Figure 7B).