ISG15 and infection: Many IFN-induced/stimulated genes with reported antiviral activity, including IFI6, IFI35, IFIT1, IFIT2, IFIT3, IRF7, ISG15, and ISG20, were found to be significantly upregulated after 6 h of infection, as well as an induced expression of various type I IFNs (Table 1), cytokines (Table 2), and chemokines (Table 3).