Moreover, two IFN-stimulated genes (ISGs), ISG15, and ISG20, as well as genes involved in ISG15 antiviral mechanism (DDX58, IFIT1, EIF2AK2, MX1, MX2, HERC5, and STAT1) were found be induced in the infected cord DCs at both time points after infection, indicating a strict regulation of cellular antiviral responses with counter balance through the induction of USP18 for both neonatal cord and adult cells (Table S1 in Supplementary Material). This evidence concerns the gene HERC5 and infection.