Finally, human 2′-5′-Oligoandenylate Synthase Like (OASL), on the other hand, has been shown to exhibit antiviral activity by enhancing specifically DDX58 signaling by mimicking polyubiquitin (104), distinguishing it from the murine OASL1 protein that negatively regulates type I IFN upon viral infection by inhibiting the translation of IRF7 mRNA (102). The gene discussed is OASL; the disease is viral infectious disease.