It had been reported that adiponectin and it receptors were expressed in human and murine cardiomyocytes (Piñeiro et al., 2005; Ding et al., 2007), and play significant roles in various cardiovascular diseases (Maia-fernandes et al., 2008; Wang et al., 2009; Villarreal-Molina and Antuna-Puente, 2012), including protecting against myocardial I/R injury (Tao et al., 2007; Wang et al., 2010; Liu et al., 2011). The gene discussed is ADIPOQ; the disease is cardiovascular disorder.