KCND2 and epilepsy: Since NMDAR and Kv4.2 reciprocally regulate each other (Kim J. et al., 2007; Jung et al., 2008) and CSEN activity is modulated by the casein kinase 1 (CK1)-mediated phosphorylation (Choi et al., 2003), it is likely that PLPP/CIN-mediated CSEN dephosphorylation would be involved in the pathophysiology of epilepsy by modulating the bindings of CSEN to NMDAR or Kv4.2 channels.