Furthermore, reductions in Kv4.2 channel expression and a mutation in the gene encoding Kv4.2 (KCND2) are reported in animal models of epilepsy (Tsaur et al., 1992; Monaghan et al., 2008) and patients with temporal lobe epilepsy (Singh et al., 2006). This evidence concerns the gene KCND2 and epilepsy.