In vitro assay using crude extracts of the PLPP/CIN-/- brains also revealed that the binding of CSEN to GluN1 was decreased to 0.71-fold of vehicle level in the presence of PLPP/CIN (n = 7, respectively, p < 0.05; Figures 6C,D and Supplementary Figure 7). This evidence concerns the gene GRIN1 and cervical squamous intraepithelial neoplasia.