NRG1 and schizophrenia: In this review, we provide a summary and perspective on information of BACE1 involvement in Nrg1 regulation in schizophrenia according to recent clinical and preclinical discoveries, presented in three sections: (1) Nrg1 structure and cleavage pattern by BACE1; (2) BACE1-dependent Nrg1 cleavage associated with schizophrenia in human studies; (3) Animal studies of Nrg1 and BACE1 mutations with behavioral observations.