While the underlying mechanisms involving NRG1 genotype in PPI are unknown, studies implicated that Nrg1 regulates NMDA receptors in specific brain regions that could induce PPI reduction and contribute to schizophrenia-like symptoms (Javitt and Lindsley, 2001; Gu et al., 2005; Hahn et al., 2006). This evidence concerns the gene NRG1 and schizophrenia.