NRG1 and schizophrenia: One study found SNP8NRG243177 in healthy young males was related to SPEM by using the root-mean-square error method (Smyrnis et al., 2011), while another study showed a significant effect of NRG1 rs3924999 genotype on ASEM amplitude gain, but not to SPEM or other variables of ASEM, in 114 healthy Caucasian subjects (Schmechtig et al., 2010), suggesting NRG1 genotypes may affect visuospatial sensorimotor transformations in general and could be a potential mechanism underlying impaired eye movements in patients with schizophrenia.