NRG1 is widely distributed in the frontal cortex, midbrain, and cerebellum (Rieff et al., 1999; Liu et al., 2001; Stefansson et al., 2003), and significantly associated with endophenotypes of schizophrenia via regulating myelination (Chen et al., 2006), neuronal migration (Ghashghaei et al., 2006), and function of neurotransmitter receptors (Liu et al., 2001; Hahn et al., 2006). The gene discussed is NRG1; the disease is schizophrenia.