A comparative analysis of baseline demographics and tumor characteristics of the AFP-negative and AFP-positive groups revealed that the former included higher proportions of patients≥60 years of age (62.2%), White (73.6%) and married (56.7%) patients, well/moderately differentiated tumors (85.9%), TNM-7-stage I/II tumors (76.5%), tumors ≤5 cm in diameter (64.4%), and F0 tumors (22.8%) (all P < 0.05). This evidence concerns the gene AFP and neoplasm.