This analysis demonstrated that LSD1 co-localizes with pTau in 56.3% of neurofibrillary tangles in AD (n = 14 patients), and with pTDP-43 in 52.4% of neurites in FTD-TDP43 (n = 5 patients) (Fig. 6g–i, n–q). This evidence concerns the gene TARDBP and Alzheimer disease.