KDM1A and early-onset autosomal dominant Alzheimer disease: Surprisingly, we also find that LSD1 mislocalizes with pathological aggregates specifically in Alzheimer’s disease (AD) and frontotemporal dementia (FTD) cases, and the genome-wide transcriptional changes in the degenerating Lsd1 hippocampus specifically correlate with those found in AD and FTD cases.