PPARGC1A and cyst: Subsequent immunohistochemical (IHC) analysis revealed a significant decrease in PGC-1α expression specifically in the kidney cyst-lining cells of ADPKD animals compared to the noncystic tubules of control animals (Fig. 3A and B), suggesting that mitochondrial abnormalities were present in the cyst-lining cells of ADPKD models.