A more recent paper by Liu and Waite13 also investigated the effect of longitudinal relationship quality on binary measures of CVD risk using outcomes of the presence or the absence of hypertension (both measured or self reported), ‘rapid heart rate’ defined as a heart rate >80 bpm and C-reactive protein >3 mg/L over 5 years of follow-up in a cohort of 739 married men and 459 women. The gene discussed is CRP; the disease is Hypertension.