The apparent discrepancy between our data and previous reports that showed increased expression of Spi‐1 in R6/2 and other HD models (Crotti et al, 2014) might reflect differences in the overall health status of the mouse colonies used in different laboratories, and/or differences in the amount of environmental enrichment provided, since both these factors are known to affect microglia phenotype (Bilbo et al, 2007; Hoogland et al, 2015; Rodríguez et al, 2015). Here, SPI1 is linked to Huntington disease.