The anti-inflammatory adipocytokine Sfrp5 modulates metabolic dysfunction during obesity in mice (Ouchi et al., 2010), and a2ml (Alpha2 macroglobulin-like) was shown to be essential for liver development in zebrafish (Hong and Dawid, 2008). The gene discussed is SFRP5; the disease is obesity due to melanocortin 4 receptor deficiency.