In patients with Alzheimer's disease (AD), MMP-14 was found overexpressed in brain (Yamada et al., 1995), which was later corroborated by studies using a transgenic mouse model where MMP-14 was found in reactive astrocytes, in regions with fibrillar amyloid deposits (Liao and Van Nostrand, 2010). This evidence concerns the gene MMP14 and early-onset autosomal dominant Alzheimer disease.