CNR2 and respiratory syncytial virus bronchiolitis: In conclusion, given the breadth of cannabinoids-mediated regulation of the immunity function and the complicated immunopathology associated with RSV infection, our results indicate that: (i) the CB2 Q63R variant is associated with the clinical course of acute respiratory viral infections (ii) experimental RSV-induced immunopathogenesis can be modulated in part by endocannabinoids, as observed by blocking the CB2 signaling, and (iii) RSV-induced immunopathogenesis can be modulated by CB2 activation and may be a novel approach for the treatment of RSV bronchiolitis in children.