While, as with all point mutations, there is always the concern that the introduced mutations might negatively affect protein folding, we believe this not to be the case in this instance for two reasons: First, the mutated mCherry-tagged polymerase is readily recruited into inclusion bodies similar to those observed previously in cells infected with a recombinant EBOV expressing L-mCherry at early time points after infection, indicating that it still has to be able to interact with the other RNP proteins. The gene discussed is RNPC3; the disease is infection.