IGHG3 and malaria: IgG3 is notable compared to other IgG subclasses: it has higher affinity for complement component C1q and Fc gamma receptors (FcγRs), a 4-fold longer flexible hinge region, that are characteristics to enhance opsonization of malaria-infected erythrocytes and promotion of effector functions such as complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and respiratory burst phagocytosis [5,6].