Using Cox proportional hazard analysis (Fig 4), there was a delay in time to first symptomatic (clinical) malaria infection as defined by a fever of >37.5°C and >2,500 parasites/μl among offspring of women with IgG3-H435 versus homozygous IgG3-R435 (HR = 0.69 [95% CI 0.37, 1.03], p = 0.08, adjusted for individual malaria exposure and placental malaria), but this difference was not statistically significant. Here, IGHG3 is linked to malaria.