IGHG3 and malaria: In the present study, an increased transplacental transfer of GLURP-R2-specific IgG3 was associated with a delay in time to first symptomatic malaria in the first year of life (Fig 3; hazard ratio [HR] adjusted for maternal placental malaria and infant malaria exposure = 0.59 [95% CI 0.45, 0.77], p < 0.001).