ESRP2 and familial pancreatic carcinoma: In human head and neck carcinoma cells, ESRP1 and ESRP2 decrease cell motility,13 and ESRP2 inhibits the proliferation of clear-cell renal cell carcinoma cells.12 In agreement with these in vitro findings, ESRP1 suppresses tumorigenic potential in colorectal cancer14 and attenuates liver metastases in pancreatic cancer in vivo.