ESRP2 and lung cancer: In normal and lung cancer cells, oncogenic EMLK-ALK kinase regulates ESRP1 and ESRP2 expression.11 Arkadia, a RING-type E3 ligase, is involved in the ubiquitination of ESRP2,12 and in this manner regulates ESRP2 expression at the post-transcriptional level in clear-cell renal cell carcinoma cells.