However, FGFR2 splicing was not affected by ectopic ESRP1 expression in our study in contrast to the known role of ESRP1 as FGFR2 splicing regulator.1 Our results are consistent with a previous study that stable transfection of ESRP1 in human pancreatic cancer cells did not change the expression of FGFR2IIIb or IIIc.15 Our results suggest that FGFR2 isoform switching by ESRP1 occurs in a cell-type-specific manner. This evidence concerns the gene ESRP1 and familial pancreatic carcinoma.