Moreover, the soluble factors of the SASP in vivo, potentially allow tumour cells to migrate through the extracellular matrix and metastasise.51 Of note, the insoluble SASP factors (fibronectin, collagen alpha-1(IV) chain, collagen alpha-2(IV) chain, laminin subunit alpha-5 and laminin subunit beta-1) (Table 1)53 were identified in EVs from TIS Cal51 cells. Here, LAMA5 is linked to neoplasm.