Pathway analysis of the contents of control EVs using IPA identified the following pathways; clatherin-mediated endocytosis signalling, systemic lupus erythematosus signalling, LXR/RXR (liver X receptor/retinoid X receptor) activation, atherosclerosis signalling and FXR/RXR (farnesoid X receptor/retinoid X receptor) activation (Figure 5b). Here, NR1H4 is linked to systemic lupus erythematosus.