STMN1 and breast cancer: Pathway analysis of the contents of the TIS EVs using Ingenuity pathway analysis (IPA) revealed the following pathways; remodelling of epithelial adherans junctions, EIF2 signalling, breast cancer regulation by stathmin 1 (Figures 5a and c, Supplementary Figure 2), phagosome maturation and epithelial adherens junction signalling pathways.