Specifically, Annexins A1 and A5 are inhibitors of phospholipase A2 signalling,35, 36 Annexin A5 is a marker of apoptosis,37 whereas Annexin A6, A11 and A2 are involved with cancer aggressiveness promoted by EVs,38 chemoresistance39 and EV-mediated angiogenesis and metastasis,40 respectively. The gene discussed is ANXA6; the disease is cancer.