RELA and cancer: There are other evidence that conditional medium from cancer cell line induced the M2 differentiation of BMDM through selective degradation of p65 by p62-dependent macroautophagy.11 In our study, we provided evidences that p65 was subjected to CMA degradation independent of its proteasome degradation, whereas hindered degradation of p65 through CMA lead to higher NF-κB activity during EMT process.