JAK2 and acute lymphoblastic leukemia: On the other hand, it has been observed that circRNAs derived from genes involved in B-cell differentiation and ALL (JAK2, PAX5, IKZF1, ETV6 and EBF1) are predominantly present in ALL compared with normal leukocytes.93 Another recent study investigated circRNA expression in acute myeloid leukemia and found several deregulated circRNAs, including a circRNA derived from WDR37. 94 Finally, Guarnerio et al.95 reported that circRNAs can be derived from transcription of fusion genes generated by chromosomal translocations.