PRKCI and neoplasm: Several circRNAs were observed to be upregulated and downregulated; however, circITCH was not among those.81 Finally, Xia et al.63 investigated the expression of a circRNA derived from exons 15 and 16 of the PRKCI gene in 51 cases of ESCC, finding it to be upregulated compared with adjacent noncancerous tissue samples and related to poor tumor differentiation and late Tumor, Node, Metastasis stage.