METTL3 and colorectal carcinoma: This reduction was negatively correlated to proliferation and the authors explain this by circRNAs accumulating in non-proliferating cells due to their high stability, while being distributed between daughter cells of proliferating cells.77 In contrast to most circRNAs, ciRS-7 was found to be upregulated in CRC, while a circRNA derived from the m6A methyltransferase gene METTL3 was the most downregulated.77 Upregulation of ciRS-7 in CRC was later also shown by Weng et al.56 in a large study comprising a training cohort of 153 primary CRC tissues and a validation cohort of 165.