TP53 and cancer: At this time, it is unknown whether circPABPN1 has a role in cancer, but it could be interesting to study as HuR is also targeting several mRNAs from tumor-suppressor and cancer-related genes, such as TP53, VHL, MYC, HIF1A and BCL2. 45 Furthermore, HuR has been shown to regulate miRNAs, including the tumor-suppressor miRNA miR-7.46 In cancer, one could also imagine that circRNAs may bind tumor-suppressor proteins preventing them from carrying out their normal cellular tasks.