Another study of a single candidate circRNA derived from the SHPRH gene found it to be significantly downregulated in 89 HCC samples relative to adjacent noncancerous tissues.86 Likewise, Yao et al.65 found a circRNA from the ZKSCAN1 gene to be significantly downregulated in 102 HCC samples compared with adjacent noncancerous tissues. The gene discussed is SHPRH; the disease is hepatocellular carcinoma.