IL-8 is a pro-inflammatory chemokine, and its increased expression in different cell types such as endothelial cells, infiltrating neutrophils, cancer cells, and tumor-associated macrophages suggests that it may be an important regulatory factor within the tumor microenvironment which promotes proliferation, survival, and migration of endothelial, cancer cells, and infiltrating leukocites [24]. The gene discussed is CXCL8; the disease is cancer.