The co-administration of AOM/DSS-TBLF reversed p53 and PCNA to basal levels, suggesting an anti-proliferative effect of TBLF, and apoptosis was confirmed by the increase of caspase 9 gene expression, a decrease of Bcl-2, and the increment of caspase 3 and cytochrome-c proteins. This evidence concerns the gene PCNA and infectious otitis media.