Another dataset from the Oncomine (available online: www.oncomine.org) [44] also showed a significant increase of Sphk1 in rectal cancers (normal mucosa 1.355 ± 0.56 vs. rectal cancer 5.94 ± 4.59 (mean ± standard deviation), p = 9.8 × 10−13) (Figure 1C). This evidence concerns the gene SPHK1 and rectal cancer.