Through deep mining of the published dataset in The Cancer Genome Atlas (TCGA) (available online: https://cancergenome.nih.gov/) [42,43], we found that Sphk1 is significantly increased in colon cancers (normal mucosa 0.20 ± 0.05 vs. 0.41 ± 0.42 in colon cancer (mean ± standard deviation), p = 9.74 × 10−7) (Figure 1A) and in rectal cancers (normal mucosa 0.20 ± 0.05 vs. 0.28 ± 0.24 in rectal cancers (mean ± standard deviation), p = 0.025) (Figure 1B). Here, SPHK1 is linked to rectal cancer.