SPHK1 and familial pancreatic carcinoma: In addition, miRNA-613 targets Sphk1 and inhibits bladder cancer cell proliferation [31], and miR-506 suppresses liver cancer angiogenesis by targeting Sphk1 mRNA [32], downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via Sphk1/Akt/NF-κB signaling [33].