The miR-659-3p/Sphk1 is involved in the regulation of chemotherapy responses of colorectal cancer cells in vivo [35], in which expression of miR-659-3p was significantly reduced in cisplatin-resistant colorectal cancer (CRC) samples, compared to cisplatin-sensitive CRC samples; in contrast, compared to cisplatin-sensitive colorectal cancers, the expression of Sphk1 was significantly increased in cisplatin-resistant samples [35]. Here, SPHK1 is linked to colorectal carcinoma.