A recent study has also reported that PF-543—a novel Sphk1 inhibitor—exerted potent anti-proliferative and cytotoxic effects against a panel of established colorectal cancer cells lines (e.g., HCT-116, HT-29, and DLD-1 cells) and primary human colorectal cancer cells through a mitochondrially programmed necrosis pathway, but not apoptosis [61]. Here, SPHK1 is linked to colorectal cancer.