Moreover, the expression of Sphk1 was significantly correlated with the expression of FAK or p-FAK, and the co-expression of Sphk1, FAK, and p-FAK was significantly associated with colorectal cancer histopathological grades, Dukes’ stages, lymph node metastasis, and distant metastasis [40,56]. Here, SPHK1 is linked to colorectal cancer.