Another study of 506 patients suggests a higher co-infection rate of 8% based on the detection of rising CRP levels at subsequent office visits; however, this is likely an overestimate since CRP measurements were made independent of microbiological confirmation [54] and it is well known that viral infections, such as influenza, parainfluenza, Epstein-Barr, herpes zoster, herpes simplex, and adenovirus may lead to substantial increases in CRP, often approaching 100 mg/mL [55,56,57,58]. The gene discussed is CRP; the disease is viral infectious disease.