In addition, STCs have emerged as possible markers of diabetes appearance and progression, as it was initially described that STC2 colocalized with glucagon in the alpha cells of the pancreas islets 4 and, later on, these authors demonstrated that contrary to healthy individuals, no correlation was found between circulating insulin and STC2 concentrations in DM2 patients 42. This evidence concerns the gene STC2 and myotonic dystrophy type 2.