As mention above UPR would be in the background of the adaptation mechanism to highly demanding diets, and it has been reported that STC2 would allow cells to survive during UPR 25, 44, 48, then facilitating cell overcome a stressful environmental conditions and to survive to deadly signalling, and even promoting cell proliferation such as occurs in certain types of cancer 49, 50. Here, STC2 is linked to cancer.