For instance, amyloid-β (Aβ) plaque accumulation caused by amyloid beta precursor protein (APP) and apoliporprotein E (APOE) genetic mutations and increased inflammation and oxidative damage have been shown to be associated with AD.42 Additionally, caloric restriction has been shown to prevent onset of neurological disorders.41 Caloric restriction activates the deacetylases sirtuins, most notably SIRT1, which is also activated by resveratrol.7 This evidence concerns the gene APP and Alzheimer disease.