As implied by its name, patients with NAFLD consume little to no alcohol, yet their livers pathologically resemble those with alcohol-induced liver damage.66 Biochemically, NAFLD is characterized by inactivation of AMPK, hepatic lipid accumulation, decreased insulin sensitivity, and inflammation.66,67 As resveratrol has been shown to decrease inflammation, activate SIRT1 and mimic effects of caloric restriction, many have predicted that resveratrol could be a potential treatment option for NAFLD. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatotic liver disease.