AKT1 and neoplasm: In vitro and in vivo studies show that resveratrol targets COXs, which generate pro-inflammatory molecules that lead to tumor proliferation, and downregulates the AKT, MAPK, and NF-κB signaling pathways, all of which would reduce inflammation and prevent tumorigenesis.22,30–32 Clinical studies, however, must determine if the same effects can be seen in human patients.