SIRT2 and Familial prostate cancer: SIRT2 has been reported to act as a tumor suppressor and as an oncogene.17 SIRT2 levels are reduced in various types of cancer such as glioma,18 liver cancer,19 esophageal adenocarcinoma20 and breast cancer,21 while they are increased in neuroblastoma,21 acute myeloid leukemia22 and prostate cancer.23 However, recent reports strongly suggest that SIRT2 plays a key role in the invasion and metastasis formation of malignancy by increasing the cell motility of cancer cells.23 On the other hand, the function of SIRT2 in neurons remains the subject of controversy.