Another recent study analyzing driver mutations in MDS pathophysiology showed that 3.5% of patients harbored inactivating mutations of the CUX1 gene   29 .CUX1 is thought to function as a tumor suppressor gene in myeloid progenitor cells by regulating the expression of proteins governing the cell-cycle 28, 29 . This evidence concerns the gene CUX1 and myelodysplastic syndrome.