RUNX1 and myelodysplastic syndrome: 3q abnormalities such as deletions, translocations and inversionsare rare occurrences in MDS but are categorized as poor-risk features due to short overall survival (median 20 months) 3,5 .Inv(3q) and t(3;3)(q21;q26) usually affect the MECOM gene at the 3q26 locus, leading to abnormal overexpression of the EVI1 (a zinc-finger nuclear protein) which results in uncontrolled proliferation and impaired differentiation of hematopoietic progenitors   45 .