ATG5 and pancreatitis: That is, animal models created with genetic inhibition of key autophagic mediators (i.e., autophagy protein 5, Atg5, or Atg7) or the glycoprotein required for lysosomal integrity (i.e., lysosomal-associated membrane protein-2, LAMP2) lack normal autophagic processing, resulting in inappropriate processing of digestive enzymes in the acinar cells and spontaneous pancreatitis.