LOXL2 and cancer: The expression pattern reflected the hallmarks of matrix remodeling seen in other cancer types, such as overexpression of lysol oxidase-like 2 (LOXL2), fibronectin, proteoglycans, factors involved in epithelial to mesenchymal transition such as lymphoid enhancer binding factor (LEF) [18–20] and αVβ6-integrin and collagen types VI and XI not normally encountered in skin [21].