Furthermore, statistical analysis of these candidates indicated that the sensitivity of 17 peptides for early diagnosis of CRC exceeded that of the conventional CRC biomarker CEA; especially, the sensitivities of three peptides of annexin A4 and A11 far exceeded the sensitivity of CEA, by > 80% when the specificity was set to 100%, (Fig. 5, Supplementary Figure 3). The gene discussed is ANXA4; the disease is colorectal carcinoma.