We tested the antiproliferative effect of pterostilbene with and without megestrol acetate in multiple endometrial cancer cells, and their anti-tumor effect in an endometrial cancer xenograft mouse model, while elucidating their effect on multiple growth and survival pathways, including JAK/STAT3, MAPK/ERK and PI3K/AKT pathways. This evidence concerns the gene AKT1 and endometrial cancer.