APEX1 and neoplasm: In that and additional works, we and others showed that APE1: (i) binds, in vitro, structured RNA molecules via its 33 amino acids N-terminal domain17; (ii) cleaves abasic single-stranded RNA, taking part in RNA-decay dependent on its endonuclease activity; (iii) has 3ʹ-RNA phosphatase and 3ʹ-exoribonuclease activities; (iv) regulates c-Myc mRNA levels and half-life in tumor cells18.