They both act as oncogenic miRNAs commonly targeting a cluster of genes with a key role in tumor inhibition, such as PTEN in tumor suppression, PUMA in apoptosis, TRPS1 in epithelial to mesenchymal transition and the cell cycle inhibitors p27Kip1 and CDKN1C/p57 50, 51. This evidence concerns the gene CDKN1B and neoplasm.