Recently, it was shown in the human Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte cell line (an in vitro cell model for studies of human adipocyte differentiation) that lipin-1 is progressively induced during adipogenesis and that depletion of lipin-1 by siRNA leads to depletion of about 95% of PAP activity and a significant reduction of the key adipogenic transcription factors PPARG and SREBP1 (30). This evidence concerns the gene LPIN1 and Simpson-Golabi-Behmel syndrome.