LPIN1 and lipodystrophy: It has been shown that adipocyte-specific Lpin1 knockout mouse models, Lpin1(fld/fld) mice carrying spontaneous inactivation of the Lpin1 gene, and Lpin11Hubr rats with mutated lipin-1 protein all unambiguously display lipodystrophy (even if each animal model is characterized by different penetrance and severity of the pathological phenotype) (1, 2, 7, 14, 23, 52).