The clinical features of rhabdomyolysis observed in human lipin-1-defective patients are compatible with those observed in Lpin1(fld/fld) mice models subjected to specific metabolic stress, in which skeletal muscle myofibrillar necrosis is also evident, due to impairment of mitochondrial functions and autophagy (29). The gene discussed is LPIN1; the disease is rhabdomyolysis.