AGPAT2 and congenital generalized lipodystrophy type 2: Mutations in the gene associated with glycerolipid synthesis, such as AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2, also known as BSCL1), are associated with congenital generalized lipodystrophy, or Berardinelli-Seip syndrome.