Lipin-1 dephosphorylates PA to DAG, a common precursor for TAG and PL synthesis (63), acting in the metabolic pathway immediately downstream of AGPAT2. Therefore, the gene products of AGPAT, LPIN1, and BSCL2 are closely functionally or physically associated, explaining how mutations in each of these genes can be directly correlated to lipodystrophy. This evidence concerns the gene LPIN1 and lipodystrophy.