INS and type 2 diabetes mellitus: High-fat diet related secretion of proinflammatory cytokines [9], endoplasmic reticulum stress via activation of toll-like receptors [10–12], activation of NLRP3 inflammasome upregulation [13] and promotion of glucose homeostasis by TNF-α blocker [14], the association of insulin resistance and dietary fatty acids with activation of B and T lymphocytes [15–17] are all evidence which may suggest the role of autoimmunity in the etiopathogenesis of T2DM.