Among genes known to cause AD, we did not detect an association for APP and PSEN2. Variant-burden analysis of PSEN1 showed strong association in our dataset; we observed 23/1886 rare variants in cases and 6/1700 in controls (burden test p = 0.0027, OR = 3.49, CI = 1.42–8.58). This evidence concerns the gene APP and Alzheimer disease.