CASP8 and early-onset autosomal dominant Alzheimer disease: However, ongoing systematic meta-analyses of Alzheimer disease genetic association studies in AlzGene database [35], and recent high-resolution exome variant microarray GWAS [36] have not identified association of chromosome 2q33.1 region which contains CASP8 with AD, indicating that it is unlikely that our results are a consequence of LD with another locus in the region.