ATP2A3 and muscle atrophy: ω-3 PUFAs preserve skeletal muscle function in humans with skeletal muscle atrophy [16,17,64] and this effect is associated with increased mitochondrial biogenesis [17,59], improved ATP resynthesis and/or sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump activity during skeletal muscle contraction [65].