Most available studies on the interplay between n-3 PUFAs and apoE relate to Alzheimer’s disease; previous findings suggest apoE4 polymorphisms to be a genetic risk factor for late onset Alzheimer’s disease [51], and epidemiological studies have postulated a clinical benefit of dietary supplementation with n-3 PUFAs in patients with dementia [51,52,53]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.