In addition, our group recently reported that human platelets express MMP12 and MMP12 can facilitate type I collagen induced platelet aggregation, adhesion, and alpha granule secretion by cleaving the CEACAM1 exodomain on platelet membrane.[9] Based on these findings, we raised the hypothesis that MMP12 is involved in coronary thrombogenesis and is potential relevance in STEMI. The gene discussed is MMP12; the disease is ST Elevation Myocardial Infarction.