The pathways include p53 signaling, transcriptional mis-regulation in cancer, insulin signaling, neurotrophin signaling, TGF-beta signaling, PI3K-AKT signaling, MAPK signaling, cell cycle, HIF-1 signaling, oocyte maturation, essential pathways related to genomic instability, cancer stem cells, cell cycle, apoptosis, invasiveness, metastasis, EMT, reproduction tissue differentiation, neurotrophin signaling and progesterone-mediated oocyte maturation. Here, INS is linked to cancer.