This mixture network contains hub proteins c-MYC, p53, YY1, SRF, PTEN, TWIST1, SMAD4, SOX2, NANOG, Elk-1 and TCF8, which play key roles in the stem cell-like properties, initiation and maintenance of the malignancy, tumor suppression, and tumor progression of HG-SOC (Fig. 4). The gene discussed is SMAD4; the disease is neoplasm.